Longboard Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company, which engages in the research and development of medicines for neurological diseases. The company is headquartered in La Jolla, California and currently employs 33 full-time employees. The company went IPO on 2021-03-12. The company is focused on developing medicines for neurological diseases. Its pipeline includes LP352 and LP659. LP352 is an oral, centrally acting, 5-hydroxytryptamine 2c receptor subtype (5-HT2c) superagonist for the treatment of developmental and epileptic encephalopathies (DEEs), including Dravet syndrome, Lennox-Gastaut syndrome, CDKL5 deficiency disorder, SCN2A-related disorders, among others. LP659 is a centrally acting, sphingosine-1-phosphate (S1P) receptor subtypes 1 and 5 (S1P1,5) modulator for inflammatory neurological conditions. LP659 is designed to avoid the negative effects connected to the receptor subtypes 2 and 3, which is associated with serious, off-target cardiac, pulmonary, and cancer-related effects. The company also has license to certain compounds including LP143, a centrally acting, full cannabinoid type 2 receptor (CB2) agonist, and compounds targeting the 5-HT2A receptor, including nelotanserin.